Gonorrhea may be fraught with such serious danger that any suggestion looking to its more intelligent and more successful treatment should receive serious consideration. Some reflections of an interesting character in this connection are entered on by Joss,2 who points out that it is impossible to destroy from without gonococci that have gained entrance into the tissues, without at the same time injuring the latter. Nor can it be conceived that the remedies used will have the desired effect, as they must diffuse through the membrane in order to reach the micro-organisms. Only the uppermost layers of epithelium are not flushed by the fluids of the body, and they will, therefore, be indifferent in their reactions to chemical solutions. Active absorption from the urethral mucous membrane does not take place. Then, even if the gonococci were destroyed, it is possible that the disease might continue, in part through the
SOME THEORETIC CONSIDERATIONS ON THE TREATMENT OF GONORRHEA. JAMA. 1900;XXXV(6):362. doi:10.1001/jama.1900.02460320032016
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