From the time, in the early part of the present century, when typhoid fever was first discriminated from a number of other diseases presenting in common with it typhoid symptoms, constant additions have been made to our knowledge of this, one of the best-studied of the infectious diseases. Not much, it is true, has been added to the original description of the anatomic lesions or of the clinical features, but, among other things, it has been made clear that the disease can not arise spontaneously, always requiring for its development the presence of the typhoid bacillus; that it may be unattended with pyrexia, and also with intestinal lesions; and, lastly, we have had developed the serum-reaction, by means of which the diagnosis can be confirmed with almost absolute certainty in the vast majority of cases. It is, therefore, perhaps not unreasonable to hope that we shall eventually come into possession
THE TREATMENT OF TYPHOID FEVER. JAMA. 1900;XXXV(7):434–435. doi:10.1001/jama.1900.02460330038005
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