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August 18, 1900


JAMA. 1900;XXXV(7):436. doi:10.1001/jama.1900.02460330040012

Glycosachthemia is the name proposed by Prichard and Colbeck1 for the condition of the system due to overloading with carbohydrates and their resultant defective metabolism. We have long assumed that the gouty or lithemic state is due to defective metabolism of nitrogenous substances, but, hitherto, as they remark, the symptoms associated with defective metabolism of nitrogenous bodies have received no distinctive name, except in the extreme cases of glycosuria and diabetes. They think it unnatural, however, that an organism phylogenetically, and actually to a large extent, carnivorous, should be subject only to the evil effects of such diet and not to effects of the excess in other directions certainly not less foreign to its nature. The authors trace up the carbohydrates in the system and take up a single group of the neutralized cleavage products that result, the lactates, as an example, and follow out the pathologic processes that