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Article
August 25, 1900

COMPARATIVE THERAPEUTIC VALUE OF DIGITALIS AND ITS DERIVATIVES.

JAMA. 1900;XXXV(8):504. doi:10.1001/jama.1900.02460340040008
Abstract

There are probably few subjects in pharmacodynamics that have been more extensively investigated and more fully discussed than the physiologic action and the therapeutic application of digitalis and its derivatives, and there has been no want of contrariety of opinion with regard to some aspects of the matter. As the result of a research undertaken with the object of harmonizing some of these differences, Arnold and Wood1 found that digitalin and digitoxin each represent the full circulatory power of digitalis. Digitalis, digitalin and digitoxin, stimulate the cardio-inhibitory mechanism, both centrally and peripherally. In larger doses they paralyze the intrinsic cardio-inhibitory apparatus. They all cause a rise of blood-pressure by stimulating the heart and constricting the blood-vessels. Excessive doses paralyze the heart-muscle in mammals, the organ stopping in diastole. Digitalin of German origin is a stable compound, 1 gram being equivalent to about 70 c.c. of tincture of digitalis. Digitoxin

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