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September 1, 1900


JAMA. 1900;XXXV(9):561. doi:10.1001/jama.1900.02460350031005

Good definitions are wanting for both inflammation and fever. Each represents a morbid process of which the manifestations are, in general, well known. The one would appear to be the result of the local reaction of the tisues to certain irritants, while the other would seem to be the result of the entrance into the circulation of chemical substances capable of causing derangement of physiologic equilibrium. Perhaps the most distinctive feature of the febrile process is elevation of temperature. The two have, in fact, even been considered synonymous, but from the view-point of precision, it were better to distinguish the latter as pyrexia. Bearing this distinction in mind, the question may be fairly raised whether fever is ever unattended with elevation of temperature, and the evidence would suggest an affirmative answer; for there are on record isolated observations in which febrile diseases, such as typhoid and scarlet fevers, have pursued