This is one of those puzzling and tantalizing diseases which will baffle a full explanation. All disease is mysterious, but we are beginning to feel that the pathology if not the treatment of diphtheria, Bright's disease, or tuberculosis is somewhat satisfactory. Many diseases of the nervous system have a beautifully exact anatomical lesion. But exophthalmic goiter, one of the most striking entities of them all, is most elusive.
The symptoms are fairly definite and yet I believe that the disease often remains unrecognized. This is so for the reason that one or more of the main symptoms may be absent or slightly in evidence. The rapid pulse is the most constant and easily detected. A pulse above one hundred, when the patient is not excited or under exertion, should arouse suspicion of this disease. Still, this marked symptom is absent in a certain percentage of cases.
The enlarged thyroid, which
HIGGINS FW. EXOPHTHALMIC GOITER. JAMA. 1900;XXXV(10):624–625. doi:10.1001/jama.1900.24620360030001f
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