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Article
September 8, 1900

RAPID GROWTH OF THE TUBERCLE BACILLUS.

JAMA. 1900;XXXV(10):629-630. doi:10.1001/jama.1900.02460360035010
Abstract

The tubercle bacillus grows but slowly upon our usual culture-media, a circumstance that causes delay in diagnostic and other investigations. Not long ago, Hesse advanced the claim that by adding a certain nutritive substance, called Naehrstoff Heyden, to agar or glycerin-agar, instead of the usual peptone, a medium is presented upon which the bacillus of tuberculosis grows with unexpected rapidity, characteristic growth being evident in two or three days. Indeed, the souring of tuberculous sputum upon this medium was said to be followed by multiplication of the bacilli in six to seven hours, as determined by microscopic examination of the surface inoculated. Hesse, on this account, leans to the opinion that all bacilli thrown off with the sputum have the power of multiplication—a fact of interest and importance if generally corroborated. Ficker2 and Römer3 have tested the results reported by Hesse. Both agree with Hesse, that on the

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