In company with its direct analogue, histological as well as in some degree functional, the skin suffers many insults from the glycosuric state, subjectively, and often bears decided objective symptoms resulting therefrom.
It never should be forgotten, though it often is, to what large degree vicarious elimination of morbid and effete matter is carried on by the skin, in its natural effort to relieve other organs in the human economy, more particularly the larger splanchnic glands, as for example the liver and kidneys, as evidenced in those cases by icterus, uridrosis, etc.
In fact, the integument must really be recognized, taken in its totality, as the largest eliminating organ of the body, which perhaps is only another way of putting the aphorism of Æsop, "that there is nothing like leather."
Skin symptoms are frequently the first to call our attention to the presence of the morbid condition which is being
SHERWELL S. CUTANEOUS MANIFESTATIONS IN DIABETES MELLITUS. JAMA. 1900;XXXV(11):676–677. doi:10.1001/jama.1900.24620370018001g
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