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October 13, 1900


JAMA. 1900;XXXV(15):952-953. doi:10.1001/jama.1900.02460410036005

The group of diseases comprehended in the designation of neuroses must be conceived to be dependent on changes in nervous structure as yet undemonstrable by present methods of investigation. There is a growing belief that aberration in function can not take place without alteration in structure—in fact, normal function must be referred to molecular changes in the cellular elements. In either instance the result is attributable to the reaction of sensitive structures to stimuli of varying degree and character. The problems opened by these and allied conceptions are almost illimitable, and we must look for their solution to the new physiological chemistry. One of the most interesting of the neuroses is migraine, which is by some considered the sensory analogue of epilepsy. Both diseases are paroxysmal or explosive, are as a rule unassociated with a gross lesion, may be preceded by an aura, be attended with hallucinations or perversions of

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