Gynecologic literature especially contains numerous references to malignant adenoma. This might lead to the supposition that the tumor was especially common in the uterus. This is, however, far from being the case, as there is probably no glandular organ, except the kidney, in which this tumor has not been found. In the lower part of the large intestine it is quite frequent; and it occurs in the biliary ducts, the gallbladder and the liver, as well as elsewhere. The reason that it has received so much attention from the side of gynecology is probably the difficulty of its differential diagnosis from benign tumors and hyperplasias. Pathologists are agreed that by malignant adenoma is understood a tumor of glandular structure that extends into the adjacent tissues and gives rise to metastases, also often of glandular type. As pointed out by Hansemann,1 its clinical course is that of carcinoma. Recidivations occur,
ADENOMA MALIGNUM. JAMA. 1900;XXXV(15):954–955. doi:10.1001/jama.1900.02460410038012
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