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October 27, 1900


Author Affiliations


JAMA. 1900;XXXV(17):1076-1079. doi:10.1001/jama.1900.24620430012001d

TOXINS IN THE TREATMENT OF TUBERCULOSIS.  The remedial use of these poisons has practically been abandoned. Inaugurated by Koch, who saw good results in the use of tuberculin in certain cases of lupus, his incomplete investigations were pushed into publicity prematurely by over-sanguine officialism in Germany, and great was the general disappointment and the damage to Koch's well-earned reputation when our hopes vanished.Later, Klebs preconized another form of tuberculin called "antithesine." Much was claimed for this so-called modified form of Koch's original tuberculin, and it was used for a while as a remedy for tuberculosis. It did not add luster to the already high reputation of this scientist, and to-day it is not in general use.Then came Dr. Von Ruck's antithesin. Von Ruck has for a few years published great promises about this agent, which he has named "watery extract" of the products of the bacillus of tuberculosis,

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