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Certainly sufficient clinical experience has now been obtained by reliable observers the world over to assign to the prevailing epidemic of influenza a place among the inflammatory neuroses. French, English, German, Italian, Russian, and American writers have noted the prominence, and often persistence of the nervous symptoms, discussing them generally as sequelæ. The initial and concomitant symptoms of influenza are so markedly those of a toxic inflammatory neurosis expending itself chiefly on the nerve coverings, nerve endings, and mucous membranes, that this aspect of its symptomatology and pathology will probably not be gainsaid by any one. The nerve centers, too, are so plainly involved as to need no proof other than what has been already offered by general clinical experience, so that its neuropathic and psychopathic accompaniments and sequences are the conditions obviously to be combated. It is a disease in the management of which the diagnostic and therapeutic experience
HUGHES CH. THE EPIDEMIC INFLAMMATORY NEUROSIS; OR, NEUROTIC INFLUENZA.Read before the St. Louis Medical Society, January 30, 1892.. JAMA. 1892;XVIII(9):245–249. doi:10.1001/jama.1892.02411130001001