[Skip to Navigation]
November 3, 1900


JAMA. 1900;XXXV(18):1159-1160. doi:10.1001/jama.1900.02460440033005

Recently two reports have emanated from San Francisco of a peculiar disease caused by a fungus. Ophüls and Moffitt,1 in their preliminary report, describe an irregularly febrile disease in a young man of 19, from the Azores. There was abundant exudation in the left pleural cavity and successive painful inflammations of various joints and other regions, irregular consolidations in the lungs, and leucocytosis. The clinical diagnosis was septicopyemia. The autopsy showed pneumonic infiltrations with abscesses, abscesses in the diaphragm, miliary abscesses and nodules in the kidneys and the liver, purulent inflammation of the frontal bone, the tibia, and various joints, with necroses in the regional lymph-glands. In all the diseased foci examined there were found encapsulated quite large organisms, whose protoplasm breaks up into numerous spore-like bodies. In addition to chronic suppuration, the organisms induce the formation of granulation tissue with giant cells often enclosing one or more parasites.