The toxicity of the urine is shown by its power to kill lower animals when injected subcutaneously. The average quantity found necessary to kill a rabbit of given weight, determines the normal uro-toxic co-efficient. This toxicity is a measure of elimination by the kidneys. MM. Roque and Weill,1 of Lyon, have recently used this method in studying the elimination of toxines in enteric fever. First allowing a typhoid patient to proceed entirely without treatment they found that the uro-toxic coefficient was doubled, which may be accepted as fairly representing the unaided efforts of nature in this disease. But that this effort is insufficient is shown by the fact that toxicity of urine remains above normal for four or five weeks after the cessation of the fever. In patients treated by cold baths the uro-toxic coefficient becomes enormously increased, reaching five or six times the normal figures. This hypertoxicity decreases
ELIMINATION OF TOXINES IN ENTERIC FEVER.. JAMA. 1892;XVIII(10):305–306. doi:10.1001/jama.1892.02411140027009
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