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November 10, 1900


JAMA. 1900;XXXV(19):1219. doi:10.1001/jama.1900.02460450035006

Mallory1 divides the injurious actions of bacterial toxins into cell necrosis, or degeneration, exudation from the blood, cell proliferation, and phagocytosis, this term being used to mean the inclusion and destruction of certain cells by other cells. The last two effects— proliferation and phagocytosis—have come into prominence more recently. As shown by Mallory, the phenomena of proliferation and cellular phagocytes are especially well marked in the lesions of typhoid fever. Similar changes occur, however, in a number of other infections: in the lymph-nodes in diphtheria; in the lungs in acute lobar pneumonia; in the kidney in scarlet fever, diphtheria, pneumococcus, staphylococcus and streptococcus infections; in the meninges and lymphnodes in some forms of tuberculosis; and Mallory describes a peculiar, nodular cystitis dependent on the accumulation of phagocytic cells in the submucosa in response to the presence of bacilli, morphologically and tinctorially, of the colon-typhoid group. It is especially endothelial