The action of iodin on the healthy body has been exhaustively studied; ideal conditions, we may say, were naturally created for such investigation. It seems that the water, soil and air, and consequently the flora of Geneva, Switzerland, are singularly free from iodin; the inhabitants of that region, therefore, constitute a virgin soil for the drug and display a remarkable susceptibility to its action.
Coindet, of Geneva, first described the physiologic effects of the drug; he was led to his studies on iodin while investigating the curative effects of sponge-preparations on goiter—bronchocele—which occurs with such frequency in Geneva; he suspected that iodin was the active remedial principle in the sponge and the other marine products that had for generations been successfully employed for the cure of this affliction. Rilliet, also of Geneva, continued these investigations and in a remarkable "Memoir" presented to the French Academy of Medicine, in 1860, first
CROFTAN AC. IODIN USED HYPODERMICALLY IN THE TREATMENT OF PULMONARY TUBERCULOSIS.. JAMA. 1900;XXXV(20):1273–1275. doi:10.1001/jama.1900.24620460023001k
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