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November 17, 1900


JAMA. 1900;XXXV(20):1281-1282. doi:10.1001/jama.1900.02460460031003

In the middle of the present century, Bence-Jones described a peculiar reaction of the urine, namely, the occurrence of turbidity on heating, or of a precipitate on addition of nitric acid, but clearing up on further heating and recurring on cooling. The substance on which this reaction depends was further found to be precipitable by alcohol, the precipitate being soluble in water. The body was recognized to be an albuminoid substance, but only many years later was it shown by Kühne to be an albumose, differing in its relations, however, from other albumoses. Since then not many cases have been placed on record in which the urine is reported to have this reaction present. The first two were considered to be instances of osteomalacia, and almost all of the others have been attended with disease of the bone-marrow for which the designation "multiple myelomata" has been proposed. The symptoms present