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November 17, 1900


JAMA. 1900;XXXV(20):1282. doi:10.1001/jama.1900.02460460032004

Pyogenic micro-organisms may gain access to the brain and give rise to the formation of an abscess through direct injury or through metastasis from a primary focus of suppuration, contiguous or remote. The most common single etiologic factor is disease of the middle ear, while the disorder is rarely a complication of the infectious diseases. A case in which an abscess of the brain developed in the sequence of an attack of typhoid fever, and giving rise to symptoms of focal epilepsy, with successful operation and discovery of staphylococci in the pus, is reported by A. C. Brown.1 The nervous symptoms made their appearance during convalescence from the fever, and infection is thought to have taken place from the intestinal tract through the medium of the ulceration of the bowel. There was no history of injury and no evidence of middle-ear disease, or of any other suppurative process. The