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This work has developed enormously since its first edition, as indeed it has had to do to keep pace with its subject. It has been necessary to change the very title of the book. When the first edition was issued ptomaines and leucomaines, alkaloidal bodies, were the only substances of bacterial or cell origin, known to be concerned in the production of disease processes. Since then, however, the very important class of bacterial proteids has been discovered, and the authors wisely generalize the title of their book, by not only including these substances, but also provide for further expansion in the term " chemical factors."
A large number of works on bacteriology are before the profession, but this is the only work which presents the chemical aspect of the question. It can hardly be doubted but that, in most instances, microörganisms produce their effects through the agency of the chemical substances
Ptomaines, Leucomaines and Bacterial Proteids; or the Chemical Factors in the Causation of Disease. JAMA. 1892;XVIII(13):405. doi:10.1001/jama.1892.02411170031016
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