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Article
December 1, 1900

THE DIAGNOSTIC SIGNIFICANCE OF ACID-PROOF (TUBERCULOID) BACILLI IN BUTTER AND ELSEWHERE.

JAMA. 1900;XXXV(22):1414-1415. doi:10.1001/jama.1900.02460480034006

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Abstract

Acid-proof and alcohol-proof bacilli, resembling B. tuberculosis, have been found in butter by Rabinowitch, Herbert, Korn and others; in grass, barn-dust and dung by Moeller; in gangrene of the lung by Rabinowitch; in the crypts of the tonsils by Marzinowsky; and in the sputum by a number of observers; also in intestinal discharges of nurslings. These organisms resemble B. tuberculosis tinctorially, and to some extent morphologically, but not in cultural characteristics. The lesions they produce in animals may be distinguishable only with difficulty from true tuberculosis by naked-eye examination. Georg Mayer has emphasized that the tuberculiform nodules that result from the injections of butter are due to the acid-proof bacilli and the butter acting conjointly. But the acid-proof bacillus recently isolated from butter by Otto Korn produces a tuberculiform disease in guinea-pigs and rabbits. The acid-proof bacilli consequently acquire diagnostic significance. It is no longer wholly and always sufficient for

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