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I wish to present guaiacol as a remedy for the treatment of painful urination, which, so far as I am aware, has not been mentioned in the therapeutics of this annoying disorder.
Frequent urination is a symptom of various affections, but guaiacol is applicable only to those cases in which the cause of the symptom is located in the extreme inner portion of the urethra, usually in a space ¾ to 1¼ inches external to the urethrovesical orifice. Many diseases of the genitourinary system cause urgent micturition, yet it is probable that all other causes combined furnish fewer cases of frequent painful urination than the one condition under consideration.
Disease of the deep urethra is, I believe, usually mistaken by the majority of general practitioners for cystitis or "irritable bladder." I am quite sure that nearly all the cases which years ago I called cystitis and irritable bladder were not
HAWES J. LOCAL USE OF GUAIACOL IN THE TREATMENT OF FREQUENT, PAINFUL URINATION. JAMA. 1900;XXXV(26):1678. doi:10.1001/jama.1900.24620520010001d
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