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January 12, 1901


JAMA. 1901;XXXVI(2):114. doi:10.1001/jama.1901.02470020042013

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At a recent meeting of the Société de Biologie, Paris, Dr. Caldas, a Brazilian bacteriologist, reported experiments on the colon bacillus of the rat. By cultivating the organism with a certain mold derived from rice, Aspergillus orizœ, and passing it from rat to rat, he finally obtained a bacillus closely resembling the typical plague germ, in great numbers from the glands, spleen, stomach and intestines of the infected animals, which produced, when injected into rats, similar clinical symptoms and was always rapidly fatal. The biologic characters of this organism throughout were the same as those of Kitasato's bacillus pestis and he has no doubt as to their equivalence. He claims, moreover, to have succeeded in rendering a horse immune by venous injections of at first very diluted cultures of the germ, followed by more virulent ones, and with this horse's serum has been able to save rats that had previously

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