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It has long been the general opinion that the colon bacillus is the essential micro-organism in acute appendicitis. The presence of this bacillus in the intestinal contents and the frequency with which it has been found in acute appendicitis in pure culture have left little room for any other opinion. There has been an idea current for a long time, however, that possibly the colon bacillus is the result of a secondary infection and that its profuse growth rapidly kills off the principal pathogenic bacteria, namely the pyogenic cocci. This idea receives strong support in the recent study of the bacteriology of 100 cases of acute appendicitis by H. C. Low.1 He made his cultures on Löffler's blood-serum. Agar plates, commonly used by many previous investigators, were found to be unreliable because they did not show cultures of all the organisms present. Streptococcus pyogenes or micrococcus lanceolatus was present
THE BACTERIOLOGY OF ACUTE APPENDICITIS.. JAMA. 1901;XXXVI(3):189–190. doi:10.1001/jama.1901.02470030045012
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