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January 26, 1901


JAMA. 1901;XXXVI(4):260-261. doi:10.1001/jama.1901.02470040038003

Cirrhosis of the liver is an exceedingly interesting process, which, in spite of the great amount of work devoted to make clear its exact etiology, still remains imperfectly understood. One reason for the comparative mystery that surrounds the exact pathogenesis of many forms of hepatic cirrhosis is the failure to discover reliable methods whereby experimental cirrhosis may be produced with certainty. Reduced largely to the study of post-mortem material, the investigators have exhausted histological and bacteriological methods without fully solving the intricate problems involved. A number of more or less distinct forms of cirrhosis of the liver have gradually been established and in the case of at least one form, namely, obstructive biliary cirrhosis, the exact etiology is now fairly well understood, largely because in this case it was possible to make suitable experiments upon animals.

William W. Ford1 presents a full review of the observations on this form