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Carcinoma is the most important of all tumors on account of its frequency and its malignancy. Its study from various aspects has consequently produced the bulkiest literature, and to-day the unsolved question of the etiology of this tumor is engaging the attention of investigators the world over. The ancient theory that carcinoma was the local manifestation of a general dyscrasia due to the excess in the body of a certain humor, is now of historical interest only; the humoral theory gave way to the belief that carcinoma was primarily of local origin, becoming general later in its course, and it is unnecessary at this time to enumerate the many clinical and anatomical facts and reasons which have led to the general acceptance of belief in the primarily local origin of carcinoma. In order to explain the origin in loco of tumors in general, Cohnheim advanced his theory of misplaced remnants
THE ETIOLOGY OF CARCINOMA. JAMA. 1893;XX(5):133–135. doi:10.1001/jama.1893.02420320023006
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