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February 16, 1901


JAMA. 1901;XXXVI(7):449-450. doi:10.1001/jama.1901.02470070035011

Wlaeff immunized geese with blastomycetic organisms obtained from malignant tumors by Curtis, Plimmer and Sanfelice. He then subjected some 26 patients with carcinomas and other tumors to treatment with the serum of the immune geese.1 The results are reported to show that the serum, which for some reason not stated is called anti-cellular, is quite harmless and free from danger; there forms a swelling at the seat of injection; the tumor itself swells up; later it diminishes in size, and eventually after repeated injections it may become encapsulated; regional lymphatic glands return to their normal size in case they are the seat of inflammatory enlargements, and those that are invaded by metastases diminish in volume. In favorable cases it is claimed that the serum may cause diminution in the size of the tumor and arrest of its evolution. Some abatement follows serum injections, also in advanced cases with ulcer