The significance of reports as to the toxicity of the urine in the presence of various morbid states will be great or little accordingly as the urine may possess toxic properties or not under conditions of apparent health. Clinicians have at different times sought to estimate the gravity of a number of diseases from a study of the toxicity of the urine, although it has been pointed out that normal urine also may be capable of injurious effects. In explanation of the latter, it has been suggested that they may be due to suspended solid elements, to the products of fermentation and to the presence of potassium salts. With the object of determining the degree of toxicity possessed by normal urine, as well as the nature of the responsible substance or substances, Dresbach1 collected the urine, usually to the amount of four liters, from healthy adults, who were not
THE TOXICITY OF NORMAL URINE.. JAMA. 1901;XXXVI(9):578–579. doi:10.1001/jama.1901.02470090042012
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