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March 2, 1901


JAMA. 1901;XXXVI(9):579. doi:10.1001/jama.1901.02470090043013

Thrombosis, especially of veins, is a not infrequent complication of infectious diseases such as pneumonia, typhoid fever, puerperal and other pyemic diseases. Thrombosis is also seen in so-called marantic states, in which death is often hastened by terminal infections. Welch, in his article on "Venous Thrombosis in Cardiac Thrombosis,"1 states that micro-organisms have been found in a large number of thrombi in cases examined in his laboratory. There seems to be but little experimental evidence in favor of the infectious nature of thrombosis under these conditions. The recent work of Jakowski,2 however, is quite suggestive. He injected sterile cultures or solutions of toxins of typhoid and of diphtheria bacilli into the circulatory blood of rabbits and guinea-pigs. After the injection a rubber band was placed around an extremity or an ear for one hour and then removed. Suitable control experiments were made and the animals killed twenty-four to