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Article
April 8, 1893

THE CHANGES IN NERVE CELLS DUE TO FUNCTIONAL ACTIVITY.

JAMA. 1893;XX(14):397-398. doi:10.1001/jama.1893.02420410021003

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Abstract

The Journal of Morphology, Vol. vii, No. 2, contains a valuable original study of the microscopic changes in nerve cells due to functional activity by C. F. Hodge, Ph.D., based upon a number of ingenious experiments upon frogs and cats and upon observations on rested and fatigued birds, bees, or chased foxes, and on the spinal cord of a hydrophobia patient. The work appears to have been carefully and conscientiously done: the technique employed is quite faultless; many of the numerous measurements were corroborated by independent observers and, on the whole, there is no single serious criticism of this research to be made. Throughout the whole all observations have been directed solely towards determining the structural changes that occur in nerve cells after periods of activity. Experiments with electrical stimulation of the afferent nerves of spinal root ganglia were conducted on frogs, dogs and cats; the results were "controlled" by

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