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May 14, 1898


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JAMA. 1898;XXX(20):1154-1155. doi:10.1001/jama.1898.72440720018001d

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Mrs. —, aged 40, has many times during the last ten years told me about attacks of palpitation which she has had and which have come on suddenly, lasted from a few seconds to ten minutes and then as suddenly stopped. Many times I have been sent for when she had been having the attacks, but the heart would have quieted before I reached her. After an attack had passed off she would be weak and exhausted for a few hours, and then be in her usual health, which in appearance was a little below normal. I could never discover any organic trouble of the heart, nor of any other organ.

Occasionally she would have attacks of urticaria, and 0.13 gram of quinia would produce intense redness all over her body. As often as every three months she had attacks of bronchial irritation, coughing almost incessantly for an hour at

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