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A review of the literature of serum therapy of the last two years is likely to produce some confusion. In the light of what has already been shown to be true, much elaborate experimentation seems to have been purposeless and final failure might have been foretold at the beginning. One of the prime causes of much misunderstanding is the failure to discriminate between the production of immunity from a disease and the production of resistance against a disease toxin. There is a wide difference between the two processes and the probable manner by which they are brought about. In the former some change, the nature of which is not understood, has been produced which makes the body unfit as a culture medium for the growth of a particular bacterium and the consequent development of its special toxin. Ten years ago Buchner showed this substance to be an albuminous body which
MADDEN J. THE LIMITATIONS OF SERUM THERAPY. JAMA. 1898;XXX(20):1164–1166. doi:10.1001/jama.1898.72440720028001i
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