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March 16, 1901


JAMA. 1901;XXXVI(11):743-744. doi:10.1001/jama.1901.02470110045011

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The germ of smallpox has heretofore received no general recognition, though the conviction that variola is a germ disease is unavoidable. The latest on this subject is to be found in the British Medical Journal for February 23, in which are two communications bearing on this subject. Dr. M. Funck, director of the Institut Sérothérapique, and chief of the bacteriologic laboratory of the University of Brussels, reports the results of his studies in this direction and the finding. in vaccin and smallpox pustules, of morphologically identical organisms which he considers as the cause of vaccinia and variola. These appear under three forms, representing different stages of the same protozoon: 1, an isolated green sphere showing slow movements; 2, the same infecting epidermic cells, and 3, a morula form consisting of agglomerated sporoblasts; the last is the one most frequently found in old vaccins, while the first form is more common

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