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April 29, 1893

Citric Acid the Important Constituent of Cancroin.

JAMA. 1893;XX(17):486-487. doi:10.1001/jama.1893.02420440024011

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To the Editor of the Journal of the American Medical Association: 

Sir:  —In your able review of Adamkiewicz' recent monograph on cancer I am pleased to note an apparent confirmation of views advanced by me more than ten years ago. In a communication to an Eastern medical journal I reported two operations upon malignant tumors of the face, in which metastases and recurrence were apparently prevented by local hypodermatic injections of a saturated solution of citric acid. The impossibility of including within the incisions all of the infected territory, without trenching upon important structures, also suggested the employment of the acid as an adjunct to the scalpel. As a result, the environing cells, which were then believed to be the fons et origo of metastatic foci, were destroyed, the tumors atrophied, and were later destroyed to save time. No recurrence within six years.More recently, December, 1890, after a cancerous

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