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March 23, 1901


JAMA. 1901;XXXVI(12):819. doi:10.1001/jama.1901.02470120043008

In 1891 von Recklinghausen directed attention to the development of osseous metastases in primary carcinoma of the prostate gland. He showed that the metastases were associated with the new formation of bone. Since then several additional cases have been reported, and recently Erbslöh described five cases of osteoplastic carcinoma from von Recklinghausen's laboratory. Three cases occurred in men, the primary tumors being prostatic, and two in women, the carcinoma in one being primary in the stomach, in the other in the bileducts. In all these cases the carcinoma had a marked tendency to infiltration. The metastatic nodules in the bones contained newly-formed osseous substance. The microscopic appearances indicated that the metastatic growths began in the form of an intracapillary infiltration which resulted in closure of the capillaries and passive congestion, the latter being regarded as the determining cause of the new formation of bone. Side by side with the osteoplastic