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June 17, 1893


JAMA. 1893;XX(24):676. doi:10.1001/jama.1893.12420510026008

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The last number of Notes on New Remedies states that a new synthetic sugar, called "dulcin," or paraphenetol carbamide, is engaging the attention of Du Bois-Raymond and other physiologists of Berlin. Kossel has been carrying on experiments on rabbits showing that the drug may be taken in doses of thirty grains daily without any disturbance of the general well-being. Dogs also have been fed with this substance for three weeks continuously, without any appreciable detriment to appetite or weight. The sweetening potency of this drug is as 200 to 1 of cane-sugar.

Dr. Ewald has tried this substance clinically and upon persons in health. He reports that it is readily taken, the taste being acceptable to all. It proved to be especially suitable to diabetic persons, given to them in "the mannite combination, one to nine." Tablets containing two-fifths of a grain of dulcin-equivalent to eighty grains of lump sugar—and

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