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Article
April 13, 1901

Fatalities of Spinal Cocainization.

JAMA. 1901;XXXVI(15):1058. doi:10.1001/jama.1901.02470150054021

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Abstract

—P. Reclus states that spinal cocainization now has a record of six deaths in Europe. Goilav and Jonnesco, of Bucharest, have each reported a fatality. In the former's case 1.5 cg. of cocain was injected and a leg amputated. Two hours later the temperature rose to 38 and 40 C., pulse 125 and death in twenty hours. Juilliard has also reported a death the second day after an operation for hydrocele and inguinal hernia. The autopsy showed a ruptured aneurysm of the Sylvian artery. The vasoconstriction induced by the cocain may have been a factor in the premature rupture of the aneurysm. Even in Tuffier's case, in which a mitral lesion and acute edema of the lung have been assigned as the cause of death, Reclus queries whether the action of the cocain may not have been a factor in the evolution of the edema. Heumberg has also reported the

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