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May 4, 1901


JAMA. 1901;XXXVI(18):1255-1256. doi:10.1001/jama.1901.02470180037004

Under certain conditions not yet perfectly understood, the secretion poured out upon the surface of mucous membranes undergoes, at times, a sort of coagulation, and as a result of this it may be discharged in irregular masses or shreds, or in the form of actual tubular casts. The disorder is most commonly encountered as occurring in the large intestine, giving rise to the symptoms of mucous or membranous colitis. The peculiar and characteristic materials discharged have been found to consist essentially of mucus, and they are considered to be the products of a secretory neurosis. They can be detached without loss of tissue, and they thus differ from diphtheritic membrane, which is an inflammatory product, with coagulation-necrosis, and which can be detached only with loss of tissue and some bleeding. Patients suffering from mucous colitis almost invariably present other evidences of a neurotic predisposition. An analogous disorder is occasionally observed