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Article
June 1, 1901

HEATED SERUM TO PREVENT INFECTION.

JAMA. 1901;XXXVI(22):1562-1563. doi:10.1001/jama.1901.02470220036003
Abstract

The serum of the normal blood has been found to contain a remarkable ferment, or group of ferments, which, when fixed by certain specific substances to bacteria and to cells of various kinds, may cause their destruction and solution. This substance or group of substances was called alexin by Buchner; it is destroyed by heat for some minutes at 55 C. Bacteriolysis, hemolysis, and cytolysis in general have been made the subject of many exceedingly interesting investigations during the past three or four years, and certain general principles have been established in regard to the actions of serums of various kinds. Thus it has been found that a large number of antiserums may be produced by first injecting animals with the special cells or bacteria or other substances upon which it is desired that the antiserum should act. The reactions that occur in experiments of this kind are exceedingly complex,

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