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June 8, 1901


JAMA. 1901;XXXVI(23):1627-1628. doi:10.1001/jama.1901.02470230029004

It would appear that two sets of affections result from deranged function of the thyroid gland, one due to excessive and the other to diminished activity. The type of those belonging in the first group is exophthalmic goiter, by the side of which it is possible there may be ranged a number of disorders that have been comprehensively included in the designation "vasomotor ataxia," such as symmetrical gangrene, morbid blushing and flushing and dermographism or factitious urticaria. In the second group belong myxedema and cretinism, probably also scleroderma and possibly adiposis.

There are on record cases in which a ease beginning as exophthalmic goiter has in the course of time been transformed into one of myxedema, and factitious urticaria not rarely appears in association with scleroderma; so that we have here evidence of the apparently paradoxic fact that there may be present in the same