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July 6, 1901


JAMA. 1901;XXXVII(1):33. doi:10.1001/jama.1901.02470270039011

The fact that physicians do not seem to be sufficiently alive to the general fact that syphilis may be the cause of obscure forms of fever, which yield only to proper antisyphilitic treatment, leads Futcher1 to report three interesting cases of this kind. The most obscure cases of this category are those in which there are no evident outward manifestations of syphilis. Futcher points out that fever in syphilis sometimes, though rarely, occurs so long as three or four weeks before the appearance of the eruption; it may occur just previously to or coincident with the secondary eruption, constituting then the so-called "fever of invasion"; and the fever may come on at any time during the secondary or tertiary stages. In one of Futcher's cases it appeared twenty-nine years after the initial lesion. Syphilitic fever may be continuous and mild, of a remittent type, and of a definite intermittent