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July 27, 1901


JAMA. 1901;XXXVII(4):269. doi:10.1001/jama.1901.02470300037013

The urine may undergo various changes in color from concentration as in the presence of fever; from the ingestion of certain articles, as rhubarb, senna, santonin, carbolic acid, methylene-blue; from the existence of certain morbid processes, as jaundice, cholera, typhus fever, pernicious anemia, melanotic sarcoma; from the presence of blood, pus, etc. The urine has been observed to be blue in those taking methylene-blue, which has been employed in the treatment of malarial fever, gonorrhea, diabetes and other affections, and also from the formation of indigo in those in whom indican is present as a result of putrefactive processes taking place in the intestines. A unique instance of the latter variety is recorded by Mr. John Good,1 occurring in an unmarried man, 43 years old, who had been drinking excessively, had vomited and complained of feeling sickly, with loss of appetite, pain in the loins over the kidneys and discolored