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A vast amount of work, clinical, anatomical and experimental, has been done in order to clear away some of the mystery surrounding the adrenals, their physiology normal and pathological. The most important affection associated with the adrenals is Addison's disease. Numerous theories have been advanced in regard to this condition, but up to the present time no single theory has proved generally satisfactory. The recent brilliant discoveries in the chemistry of these glands have culminated in the isolation of certain substances with powerful actions, especially in raising the blood pressure, but their exact rôle in normal physiologic processes is not yet fully understood. It has been thought that the symptoms of Addison's disease in some way are explainable as dependent upon the suspension or perversion of the internal secretion of the adrenals owing to the fact that they are largely destroyed or replaced especially by tuberculous products in this disease.
EXPERIMENTAL TUBERCULOSIS OF ADRENALS.. JAMA. 1901;XXXVII(7):452. doi:10.1001/jama.1901.02470330034002
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