Laking of red corpuscles may occur from different causes. It takes place in solutions of less concentration —hypotonic—than the blood serum, and also under the influence of certain toxic substances no matter if the concentration of the fluid medium is quite the same as the blood serum—isotonic. It has been found that under certain conditions the urine may cause the laking of blood. This may be because the urine is hypotonic, but it may also depend upon other factors.
Indeed, there may be hemolytic substances in the urine which seem to be prevented from causing hemolysis because of the hypertonicity of the urine, as Hamburger and, following him, Camus and Pagniez,1 showed by adding a few drops of urine to non-hemolytic solutions of sodium chlorid (0.66 to 0.70 per cent.) and mixing in a few drops of blood. After an hour or two in the incubator more or less
GLOBULICIDAL ACTION OF URINE.. JAMA. 1901;XXXVII(9):583. doi:10.1001/jama.1901.02470350039006
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