In 1886 acromegaly was first introduced to the medical world, through the report of Marie, the name having been applied by him to a disease characterized by a progressive enlargement or overgrowth of certain portions of the body, all tissue being more or less involved, and the hands, feet and face being the earlier and chief seats of the morbid change. There can be no doubt concerning the close relation of acromegaly to giantism; indeed, it may be regarded as a sort of localized giantism, due to certain limitations in the pathologic seat and process, or to the age at which the disease begins. Acromegaly is so strikingly objective in its symptomatology that one finds it difficult to explain how it could have been disregarded for so many centuries. Up to 1891 only 37 cases had been reported, yet in 1893 the number had reached 83; in 1898, 218 had
GREENE CL. A CASE OF ACROMEGALY PRESENTING CERTAIN FEATURES OF UNUSUAL INTEREST. JAMA. 1901;XXXVII(14):887–890. doi:10.1001/jama.1901.62470400011001b
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