The many recent and. valuable discussions of the cancer question, notably Senn's comprehensive review in a late number of this journal, Park's exposition of the parasitic theory in The Journal.1 and C. P. White's2 amplification of Ribbert's theory of tissue tension, omit one important feature in the biology of malignant tumors, namely, the rarity with which the epithelial and mesoblastic types of malignant growths occur together. This fact, however, is of much importance. In his report of a primary tumor in the thyroid gland of a dog, which was composed of an intimate admixture of the two types, H. G. Wells3 states that his search of the literature revealed but seventeen cases in which it was demonstrated with reasonable accuracy that a single individual presented simultaneously an independent carcinoma and an independent sarcoma. This does not tend to support the assumption of White that the general condition
THE INFREQUENCY OF PRIMARY MALIGNANT TUMORS OF MIXED TYPES AND ITS BEARING ON THE CANCER QUESTION. JAMA. 1901;XXXVII(15):980–981. doi:10.1001/jama.1901.02470410032004
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