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October 26, 1901


Author Affiliations

Professor of Neurology, Chicago Policlinic; Clinical Professor of Nervous Diseases, Northwestern University Medical School: Neurologist to the German, Passavant, Maurice Porter and Wesley Hospitals. CHICAGO.

JAMA. 1901;XXXVII(17):1100-1102. doi:10.1001/jama.1901.62470430024001e

This paper takes no cognizance of inherited syphilis or of the degenerative diseases in some way caused by specific infection, but is limited to the signs of histologically definable specific invasion of the brain.

Before entering upon the details of my subject, I beg indulgence while I enunciate half a dozen postulates relating to the clinical history and more general symptomatology of cerebral lues, which seem to me so important as to be inevitable as a preface.

  1. Brain syphilis is most frequent in the first year after infection, next most frequent in the second year, less frequent in the third year and so on, about 50 per cent. of all cases occurring within three years after the primary sore. After ten years of quiescence, therefore, the appearance of cerebral syphilis is exceptional.

  2. In reaching a diagnosis of a brain case, absence of a history of specific infection should