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Article
November 9, 1901

THE INFLUENCE OF CONCENTRATION AND OF THE NUMBER OF SITES FOR HYPODERMIC INJECTION.

JAMA. 1901;XXXVII(19):1254. doi:10.1001/jama.1901.02470450034007
Abstract

There is a belief in some quarters that drugs taken in undiluted form are more active than when taken diluted, but this view is not generally accepted. It would on the same line of reasoning be expected that medicaments administered hypodermically would be the more active the more concentrated their form. Of this, some observations recorded by Dr. S. J. Meltzer1 would seem to supply evidence, as well as of the further fact that the intensity of action can be increased by making the injection in more than one situation. The observations were made in the course of experiments disproving an assertion that had been made to the effect that animal tissues are capable of neutralizing or fixing the poisons of strychnin and venom. When the minimum effective dose of strychnin divided into three equal parts was injected into three of the previously ligated extremities of a guinea-pig violent

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