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November 9, 1901

Fatal Results from Diphtheria Antitoxin in St. Louis.

JAMA. 1901;XXXVII(19):1260-1261. doi:10.1001/jama.1901.62470450032014

In reply to a request for information in regard to the deaths from antitoxin in St. Louis, Dr. Mac C. Starkloff, Health Commissioner of St. Louis, writes to The Journal under date of November 6: "... On the afternoon of October 26, I received a communication from a physician saying that he had under his observation two cases of tetanus which were undoubtedly caused by the diphtheria antitoxin furnished by the Health Department. I immediately ordered that the distribution of antitoxin be at once discontinued, and addressed a letter to Dr. Amand Ravold, our consulting bacteriologist, by whom our antitoxin is made, asking for information in regard to the production of antitoxin. I enclose a copy of his reply.

"Following the reports of death from tetanus claimed to have been produced by the antitoxin, I had a conference with Dr. R. M. Funkhouser, coroner, and an investigation was begun. Also a

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