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November 16, 1901


Author Affiliations

Professor of Ophthalmology and Otology, Central Medical College. ST. JOSEPH, MO.

JAMA. 1901;XXXVII(20):1290-1292. doi:10.1001/jama.1901.62470460004001b

Definition.  —A subacute or chronic infection of the Meibomian glands, tending to periodical acute exacerbations and, secondarily, altering the whole structure of the tarsal cartilages, chiefly the upper.

Etiology.  —Diffusion through part, or all, of the Meibomian glandular system of chalazial disintegration products and their cause.

Pathogenesis.  —Chalazia representing unhealthy granulation tissue of a very low type, scantily supplied with blood vessels, tend, from this nature of their make-up, to break down. The age of the patient and the condition of the general health modify this tendency to disintegration, great youthfulness and general debility favoring a destruction more or less acute, while more advanced age and good health favor chronicity. This circumstance is due merely to varying degrees of body resistance. Chalazia may, therefore, undergo, 1, suppuration; 2, chronic inflammatory softening.1. Suppuration may be so severe as to bring about not only the destruction of the neoplastic tissue, but

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