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A few years ago, when the microscope first began to clear up the mists which pervaded medicine, and when the excretions of the body received attention due them, many observers were not slow in finding in the sediment of the urine bodies which were denominated casts. Some observers went further than this, and a few years ago it was thought possible to differentiate the different varieties of nephritis by the kind of cast found in the urine, attributing the hyalin cast to the interstitial variety and the granular to the parenchymatous. But even before this time the urine had received attention, and albumin had been demonstrated by chemic methods. Clinical experience had told them of the pallor of the skin, of the hardened arteries and of the edema which was sometimes present.
Combining these facts obtained by clinical experience with the occurrence of albumin and casts in the urine it
WHAT ARE THE SYMPTOMS OF NEPHRITIS? JAMA. 1898;XXXI(4):188. doi:10.1001/jama.1898.02450040038005
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